Cisztatin C
Más néven:
Hivatalos név:
Cisztatin C
Másnéven: 25-Hidroxi-D vitamin (Kalcidiol); 1.25 Dihidroxi-D vitamin (Kalcitriol)
012.  A cikk utoljára módosult: 27.10.2017.
Mire való a vizsgálat?

Ismert vagy gyanított vesebetegség esetén a vesefunkció megítélésére használható, de csak olyan esetekben, amikor a hagyományos vesefunkciós vizsgálatok eredménye félrevezető lehet.

Mikor kell a vizsgálatot elvégezni?

Ha kezelőorvosa arra gyanakszik, hogy önnek vesefunkciózavara van, de a szérum kreatininszint mérés eredménye nem megbízható. Ismert vesebetegség esetén rendszeres időközönként kérhetik a vizsgálatot.

Milyen mintára van szükség?

A kar egy könyökhajlati vénájából vett vérmintára.

Hogyan készüljek elő a vizsgálatra?

A vizsgálat nem igényel különleges előkészületet.

Áttekintés

No items found.

Vizsgálat

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Gyakori kérdések

Mire való a vizsgálat?
Mikor kéri az orvos a vizsgálatot?
Mit jelent a vizsgálati eredmény?
Mit kell még tudnom?
A cisztatin C szint mérhető a vizeletből is?
Hogyan számolják az eGFR-t?
Van lehetőség a GFR pontos meghatározására?

Kapcsolódó oldalak

Laboratóriumi vizsgálatok
No items found.
Állapotok és betegségek
No items found.

Máshol az interneten

No items found.

Felhasznált irodalom

Aktuális áttekintésben használt források

2017 review performed by Joshua E Raizman, PhD, FCACB.

Ebert N, Delanaye P, Shlipak M, Jakob O, Martus P, Bartel J, Gaedeke J, van der Giet M, Schuchardt M, Cavalier E, Schaeffner E. Cystatin C standardization decreases assay variation and improves assessment of glomerular filtration rate. Clin Chim Acta. 2016 May 1;456:115-21.

Kidney Disease Improving Global Outcomes, KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Available online at http://www.kdigo.org/clinical_practice_guidelines/pdf/CKD/KDIGO_2012_CKD_GL.pdf. Accessed April 2017.

Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS.; CKD-EPI Investigators Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012 Jul 5;367(1):20-9.

Waheed S, Matsushita K, Sang Y, Hoogeveen R, Ballantyne C, Coresh J, Astor BC. Combined association of albuminuria and cystatin C-based estimated GFR with mortality, coronary heart disease, and heart failure outcomes: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis. 2012 Aug;60(2):207-16.

Dalcomune DM, Terrão J, Porto ML, Vasquez EC, Baldo MP, Pereira TM. Predictive value of cystatin C for the identification of illness severity in adult patients in a mixed intensive care unit. Clin Biochem. 2016 Jul;49(10-11):762-7.

Brown CS, Kashani KB, Clain JM, Frazee EN. Cystatin C Falsely Underestimated GFR in a Critically Ill Patient with a New Diagnosis of AIDS. Case Rep Nephrol. 2016;2016:9349280.

©2014 National Kidney Foundation. Frequently asked questions about GFR estimates. Available online at https://www.kidney.org/sites/default/files/docs/12-10-4004_abe_faqs_aboutgfrrev1b_singleb.pdf. Accessed 26/04/2017.

Korábbi áttekintések során használt források

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Jeffrey, S. (2006 August 16). Cystatin C May Identify Pre-CKD in Elderly With Normal eGFR. Medscape Medical News [On-line information]. Available online at http://www.medscape.com/viewarticle/543019.

Jeffrey, S. (2005 September 6). Cystatin C is a sensitive marker of prognosis acute heart failure. Medscape Medical News [On-line information]. Available online at http://www.medscape.com/viewarticle/538789.

Shlipak, M. (2005 May 19). Cystatin C and the Risk of Death and Cardiovascular Events among Elderly Persons. NEJM v 352(20) 2049-2060 [On-line journal]. Available online at http://content.nejm.org/cgi/content/short/352/20/2049.

Sarnak, M. (2005 April 5). Cystatin C Concentration as a Risk Factor for Heart Failure in Older Adults. Annals of Internal Medicine v142(7) [On-line information]. Available online at http://www.annals.org/cgi/content/abstract/142/7/497?ct.

Villa, P. et. al. (2005 April). Serum cystatin C concentration as a marker of acute renal dysfunction in critically ill patients. Crit Care. 2005; 9(2): R139-R143 [On-line journal]. Available online at http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=1175926.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 328-329.

Clarke, W. and Dufour, D. R., Editors (© 2006). Contemporary Practice in Clinical Chemistry: AACC Press, Washington, DC. Pp 312.

Lowry, F. (2009 February 27). Cystatin C, High Levels of Serum Cystatin C and Chronic Kidney Disease Linked to Age-Related Macular Degeneration. Medscape Medical News [On-line information]. Available online at http://www.medscape.com/viewarticle/588857. Accessed October 2009.

Ma, Y-C. et. al. (2008 January 28). Improved GFR Estimation by Combined Creatinine and Cystatin C Measurements. Medscape Today from Kidney International [On-line information]. Available online at http://www.medscape.com/viewarticle/568609. Accessed October 2009.

Craig, R. G. and Hunder, J. M. (2008 October 27). Recent Developments in the Perioperative Management of Adult Patients with Chronic Kidney Disease. Medscape Today from British Journal of Anaesthesia [On-line information]. Available online at http://www.medscape.com/viewarticle/581312. Accessed October 2009.

(2009 January 27). New Equation Accurately Estimates GFR in Children With Kidney Disease. Medscape Today from Reuters Health Information [On-line information]. Available online at http://www.medscape.com/viewarticle/587379. Accessed October 2009.

(Updated 2009 August). Renal Function Markers - Kidney Disease. ARUP Consult. [On-line information]. Available online at http://www.arupconsult.com/Topics/RenalFunctionMarkers.html?client_ID=LTD. Accessed October 2009.

(April 7, 2009) National Kidney Disease Education Program, Laboratory Professionals: Update on Cystatin C. Available online at http://nkdep.nih.gov/labprofessionals/update-cystatin-c.htm. Accessed January 2010.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, Pp 153-154.

Lerma, E. (Updated 2012 May 17). Novel Biomarkers of Renal Function. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1925619-overview. Accessed July 2013.

Sinert, R. and Peacock, P. (Updated 2013 June 20). Acute Renal Failure Complications. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/777845-overview#a1. Accessed July 2013.

Malone, B. (2012 August 23). Refining the Role of Cystatin C in Estimating GFR New Combined Cystatin C –Creatinine Equation More Accurate. Clinical Laboratory Strategies [On-line information]. Available online at http://www.aacc.org/publications/strategies/archives/2012/Documents/082312CLS.pdf. Accessed July 2013.

(© 1995–2013). Cystatin C with Estimated GFR, Serum. Mayo Clinic Mayo Medical Laboratory Interpretive Handbook [On-line information]. Available online at http://www.mayomedicallaboratories.com/interpretive-guide/?alpha=C&unit_code=35038. Accessed July 2013.

Paxton, A. (2012 September). Cystatin C and creatinine—using both found to be best. CAP Today [On-line information]. Available online through http://www.cap.org. Accessed July 2013.

Shah, A. (Revised 2013 May). Evaluation of the Renal Patient. Merck Manual for Healthcare Professionals [On-line information]. Available online through http://www.merckmanuals.com. Accessed July 2013.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 326-333.

Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 363-366.

McPherson, R. and Pincus, M. (© 2011). Henry's Clinical Diagnosis and Management by Laboratory Methods 22nd Edition: Elsevier Saunders, Philadelphia, PA. Pp 177.

Zhou H, Hewitt SM, Yuen PS, Star RA. Acute Kidney Injury Biomarkers - Needs, Present Status, and Future Promise. Nephrol Self Assess Program. Mar 2006;5(2):63-71. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603572/. Accessed August 2013.

National Kidney and Urologic Diseases Information Clearinghouse. Kidney Disease Research Updates, Winter 2013. NIH-funded Study Finds More Precise Way to Estimate Kidney Function. Available online at http://kidney.niddk.nih.gov/About/ResearchUpdates/KidneyWin13/5.aspx. Accessed October 2013.

National Kidney Foundation. Cystatin C: What is its role in estimating GFR? Available online at http://www.kidney.org/professionals/tools/pdf/CystatinC.pdf. Accessed October 2013.

National Kidney Disease Education Program. Estimating GFR. Available online at http://nkdep.nih.gov/lab-evaluation/gfr/estimating.shtml. Accessed October 2013.

National Kidney Disease Education Program. Update on Cystatin C: Cystatin C Standardization (Update as of July 2010). Available online at http://nkdep.nih.gov/lab-evaluation/cystatin-c.shtml. Accessed October 2013.

UCSF (Karin Rush-Monroe on September 04, 2013). Kidney Function Can Be Assessed by Measuring Cystatin C in Blood. Available online at http://www.ucsf.edu/news/2013/09/108666/relationship-kidney-function-estimates-risk-improves-measuring-cystatin-c-blood. Accessed October 2013.

Shlipak MG et al. Cystatin C versus Creatinine in Determining Risk Based on Kidney Function. N Engl J Med 2013; 369:932-943, September 5, 2013. Available online at http://www.nejm.org/doi/full/10.1056/NEJMoa1214234. Accessed October 2013.

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Karbamid

Conditions

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Diabétesz (Cukorbetegség)

Elsewhere On The Web

https://www.niddk.nih.gov/health-information/kidney-disease

https://www.kidney.org/patients

https://medlineplus.gov/kidneydiseases.html

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