Az apolipoprotein E (APOE) genotipizálását rendszerint kutatások részeként végzik a szív-érrendszeri betegségek genetikai hátterének megértése céljából. Olykor azonban a diagnosztikában is alkalmazzák a III-as típusú hiperlipoproteinémia (más néven familiáris diszbétalipoproteinémia) diagnózisának felállítására.
Amikor az orvos úgy gondolja, hogy a magas koleszterin- és trigliceridszint hátterében örökletes tényező is állhat, illetve, ha a bőrön sárgás elváltozások, ún. xantómák figyelhetők meg.
A kar könyökhajlati vénájából vett vérmintára vagy szájnyálkahártya-törletre.
Nincs szükség előkészületre.
Aktuális áttekintésben használt források
2017 review performed by Allison B. Chambliss, PhD, DABCC, FACB, Scientific Director, LAC+USC Medical Center Core Laboratory.
Mahley RW, Weisgraber KH, and Huang Y. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res. 2009 Apr; 50(Suppl): S183–S188. Available online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674716/. Accessed Sept 2017.
Bays HE, Jones PH, Orringer CE, Brown WV, Jacobson TA. National Lipid Association Annual Summary of Clinical Lipidology 2016. J Clin Lipidol. 2016 Jan-Feb;10(1 Suppl):S1-43. doi: 10.1016/j.jacl.2015.08.002. Available online at https://www.ncbi.nlm.nih.gov/pubmed/26891998 http://nlaresourcecenter.lipidjournal.com/Content/PDFs/Appendix-Final.pdf. Accessed Sept 2017.
Rosenson RS. Lipoprotein classification, metabolism, and role in atherosclerosis. UpToDate. Last updated May 05, 2017. Available online at https://www.uptodate.com/contents/lipoprotein-classification-metabolism-and-role-in-atherosclerosis?source=search_result&search=apolipoprotein%20e&selectedTitle=4~53. Accessed Sept 2017.
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Tests
Conditions
Kardiovaszkuláris betegség (CVD)
https://ghr.nlm.nih.gov/gene/APOE