Segít megállapítani, hogy mi áll az ismeretlen okból fellépő túlzott vérzés vagy ismétlődő vérzések hátterében; segít a von Willebrand betegség (vWB) diagnosztizálásában, és a vWB különböző típusainak elkülönítésében.
Ha önnél vagy az ön családjában előfordult súlyos, elhúzódó és/vagy spontán vérzés; ha orvosa azt gyanítja, hogy önnél véralvadási zavar áll fönn.
A kar könyökhajlati vénájából vett vérre.
Nem igényel különleges előkészületet.
Aktuális áttekintésben használt források
2018 Review completed by Rita Khoury, MD, DABCC, FACB, Laboratory Director, Aculabs, Inc.
Stuijver DJ; Piantanida E; van Zaane B; Galli L; Romualdi E; Tanda ML; Meijers JC; Büller HR; Gerdes VE; Squizzato A. Acquired von Willebrand syndrome in patients with overt hypothyroidism: a prospective cohort study. Haemophilia. 2014; 20(3):326-32
Waldow HC; Westhoff-Bleck M; Widera C; Templin C; von Depka M. Acquired von Willebrand syndrome in adult patients with congenital heart disease. Int J Cardiol. 2014; 176(3):739-45 (ISSN: 1874-1754)
Roberts JC; Flood VH. Laboratory diagnosis of von Willebrand disease. Int J Lab Hematol. 2015; 37 Suppl 1:11-7 (ISSN: 1751-553X)
Hayward CP; Moffat KA; Graf L. Technological advances in diagnostic testing for von Willebrand disease: new approaches and challenges. Int J Lab Hematol. 2014; 36(3):334-40 (ISSN: 1751-553X)
Tosetto A. Bleeding Assessment Tools: Limits and Advantages for the Diagnosis and Prognosis of Inherited Bleeding Disorders. Semin Thromb Hemost. 2016 Jul. 42 (5):463-70.
Gill JC, Castaman G, Windyga J, Kouides P, Ragni M, Leebeek FW, et al. Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease. Blood. 2015 Oct 22. 126 (17):2038-46.
[Guideline] Laffan MA, Lester W, O’Donnell JS, Will A, Tait RC, Goodeve A, et al. The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology. Br J Haematol. 2014 Aug 12.
Korábbi áttekintések során használt források
Yawn, B. et. al.(2009 December 1) Diagnosis and Management of Von Willebrand Disease: Guidelines for Primary Care. American Family Physician [On-line information]. Available online at http://www.aafp.org/afp/2009/1201/p1261.html. Accessed February 2010.
Pagana, K. D. & Pagana, T. J. (© 2007). Mosby’s Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 280.
Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 1144-1145.
Rodgers, III, G. and Smock, K. (Updated 2009 August). von Willebrand Disease – vWD. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/vWD.html?client_ID=LTD. Accessed February 2010.
(Revised 2009 May). What Is von Willebrand Disease? National Heart Lung and Blood Institute [On-line information]. Available online at http://www.nhlbi.nih.gov/health/dci/Diseases/vWD/vWD_WhatIs.html. Accessed February 2010.
Geil, J. (Updated 2009 May 21). Von Willebrand Disease. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/959825-overview. Accessed February 2010.
Goodeve, A. and James, P. (2009 June 4). von Willebrand Disease. GeneReviews [On-line information]. Available online at http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene∂=von-willebrand. Accessed February 2010.
Mayo Clinic Staff (2009 February 7). Von Willebrand disease. MayoClinic.com [On-line information]. Available online at http://www.mayoclinic.com/health/von-willebrand-disease/DS00903. Accessed February 2010.
George, J. (Revised 2009 May). Von Willebrand’s Disease. Merck Manual for Healthcare Professionals [On-line information]. Available online at http://www.merck.com/mmpe/sec11/ch133/ch133h.html#sec11-ch133-ch133h-410. Accessed February 2010.
Grund, S. (Updated 2008 March 21). Von Willebrand disease. MedlinePlus Medical Encylopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000544.htm. Accessed February 2010.
Link, R. (Updated 2009 March 4). Bleeding Disorders, Frequently Asked Questions. Womenshealth.gov [On-line information]. Available online at http://www.womenshealth.gov/faq/bleeding-disorders.cfm. Accessed February 2010.
Clarke, W. and Dufour, D. R., Editors (© 2006). Contemporary Practice in Clinical Chemistry: AACC Press, Washington, DC. Pp 236-237.
Henry’s Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007 pp 760-762.
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Medscape Editorial Staff (Updated 2012 October 1). von Willebrand Factor Antigen (Factor VIII:R Antigen) Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/2086366-overview. Accessed November 2013.
(2011 June 1). What Is von Willebrand Disease? National Heart Lung and Blood Institute [On-line information]. Available online at http://www.nhlbi.nih.gov/health/health-topics/topics/vwd/. Accessed November 2013.
Heikal, N. et. al. (Updated 2013 October). von Willebrand Disease – VWD. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/VWD.html. Accessed November 2013.
Gersten, T. (Updated 2012 February 16). Von Willebrand disease. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000544.htm. Accessed November 2013.
(© 1995–2013). von Willebrand Profile. Mayo Clinic Mayo Medical Laboratory [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/83099. Accessed November 2013.
Pagana, K. D. & Pagana, T. J. (© 2011). Mosby’s Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 277.
Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 277-279.
McPherson, R. and Pincus, M. (© 2011). Henry’s Clinical Diagnosis and Management by Laboratory Methods 22nd Edition: Elsevier Saunders, Philadelphia, PA. Pp 816-819.
(Updated 1, 2011) National Heart Lung and Blood Institute. What is von Willebrand Disease? Available online at http://www.nhlbi.nih.gov/health/health-topics/topics/vwd/. Accessed November 2013.
Tests
APTI (Aktivált parciális tromboplasztin idő)
KidsHealth from Nemours: von Willebrand Disease
Centers for Disease Control and Prevention: Bleeding Disorders in Women
Centers for Disease Control and Prevention: Von Willebrand Disease (VWD)
World Federation of Hemophilia: What is von Willebrand disease (VWD)?
Canadian Hemophilia Society: Heredity of von Willebrand disease
National Hemophilia Foundation: von Willebrand disease
National Heart, Lung, and Blood Institute: Von Willebrand Disease